Probably not, because OneP has no concept of "who" is connecting. Can you validate the CIK that your python app uses for authentication?
Do you have Exoline installed? I don't meant to keep harping on it, but it is a tool that I use daily.
$ exo twee $CIK
That command would be a quick test of the CIK. If you get a small tree of your client and its resources, your app may be using the wrong auth. If you get a 401 you will know that the CIK you had been using has become invalid.
Happy to help,